Is There A Role For Intravitreal Pharmacotherapy In The Treatment Of Acute Nonarteritic Ischemic Optic Neuropathy?

Abstract

Purpose: To reviewthe safety and efficacy of intravitreal pharmacotherapy in  the treatment of acute nonarteritic anterior ischemic optic neuropathy (NAION).

Context:Early reports on acute NAION indicated that no therapy was effective enough to improve the natural outcome of the disease . Till now on, a large number of therapeutic modalities have been tried but none has turned out to bethe gold standard. Today,intravitreal pharmacotherapy, which provides sufficient vitreous drug concentrations in the eye is widely employed in various retinal disorders successfuly.

Method: A thorough literature search was conducted in May 2016 to retrieve all manuscripts related to acuteNAIONtreatment and we particularly focused on manuscripts about intravitreal therapy.

Conclusion:Today, the role of intravitreal pharmacotherapy in NAION is still not well-established. It is evident that only randomized-controlled trials can give a scientific answer and clarify the place of intravitreal pharmacotherapy in the treatment of acute NAION.