The Function of Stress-induced Transcriptional Regulator p8 in Solid Tumors

Abstract

Abnormal transcriptional regulation of the tightly sophisticated collaboration under stressful conditions is a critical aspect of tumorigenesis and progression. The transcriptional regulator p8 or NUPR1 (nuclear protein-1) or Com1 (candidate of metastasis-1) is one of the proteins related to the high mobility group. p8 is first identified during acute pancreatitis, and its expression is upregulated in certain types of solid tumors. p8 can be induced in response to intracellular and extracellular stresses with variant functions depending on contextual cues. On one hand, p8 plays an important role in the progression of several solid tumors, including thyroid, breast, brain and pancreatic tumors. On the other hand, p8 also acts as a tumor suppressor in some kinds of solid tumors including prostate and colorectal tumors. Deciphering the mechanisms of p8 regulation and its function will provide new strategies for solid tumors treatment with more efficacy.