The association of uterine leiomyomas with p53 codon 72 polymorphism. A confirmation study in the Italian population

Fulvia Gloria-Bottini, M Ammendola, A Pietropolli, A Neri, A Magrini, E Bottini

Abstract


Aim: To confirm the excess of *Pro/*Pro genotype of p53 codon 72 polymorphism in uterine leiomyomas as compared to controls  observed in the population of Freiburg.

Material and Methods: 205 women admitted to the Hospital for leiomyomas requiring surgical intervention and 258 controls werestudied in the population of Rome. p53 codon 72 genotype was determined by DNA analysis.

Results: An excess of *Pro/*Pro genotype (21.9%) in women with leiomyomas as compared to controls (7.4%) is observed in Rome: such association is identical to that observed in Freiburg.

Conclusion: The present study confirms the association between p53 codon 72 with uterine leiomyomas reported in the population of Freiburg. Determination of the genotype of this system could help to identify women with high risk of severe clinical manifestation of uterine leiomyomas.


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