Mini Review: Relationship Between Platinum Induced Toxicities and Nucleotide Excision Repair (NER) Pathway Polymorphisms in Non-Small Cell Lung Cancer (NSCLC) Patients and Beyond

Abstract

Platinum-induced toxicities severely impede successful chemotherapy in non-small cell lung cancer (NSCLC) patients. The nucleotide excision repair (NER) pathway is considered as one of the major factors contributing to platinum effects. Furthermore, genetic variances of the NER pathway influence platinum toxicities. Several genetic loci have recently been reported to contribute to the susceptibility of platinum-induced toxicities. In order to further understand the genetic influence on the risk of platinum-induced toxicities in NSCLC patients, we reviewed and collected articles from PUBMED for genes that reported by recent clinical pharmacogenetic studies. At the conclusion of our search, we summarized the publications about relative clinical trials and summarized five candidate genes, which might relate with platinum-induced toxicities in NSCLC patients. Despite the findings of this and other similar, contemporary research projects, many of the special details and underlying mechanisms in this field of study are still, to a great extent, unknown. As a result, future studies are needed to gain a full appreciation regarding the identification of high toxicity risk in human beings