Current Definitions and Therapeutic Strategies for Esophagogastric Cancer: A Medical Oncologist’s Perspective

Abstract

Gastroesophageal junction carcinoma is a challenge to medical oncologist due to issues in staging and classification and uncertainties reagrding optimal treatment approach. As a comprehensive review of Status of Arts in gastroesophaeal junction carcinoma, this article discusses its anatomical, histological, and endoscopic definition, classification, and advances in surgery, neoadjuvant therapy, adjuvant therapy, and innovative molecualr targeting therapy. In general, anatomical and histological definitions are important for diagnosis and treatment of gastroesophaeal junction carcinoma. Combination of surgery and adjuvant therapy is more beneficial for patients with gastroesophaeal junction carcinoma than surgery alone.