Therapeutic Approaches for Treatment of Gliomas

Sura Zaki, Sha Jin

Abstract


Although tremendous research efforts have been made, cancer remains one of the leading causes of death worldwide. Glioblastoma multiforme (GBM) is the most aggressive primary malignant brain tumor due to its highly heterogeneity and resistance to standard treatment approaches. Poor survival rate in gliomas patients related to the presence of blood-brain barrier (BBB) which represents potent obstacle against a wide range of drugs including most anticancer agents. Many novel strategies have been developed to improve glioma prognosis and treatment by designing delivery systems for targeting therapies that specifically attack cancer cells without causing damage to surrounding healthy brain tissue. These targeted therapies are often promising, but with limited progress upon clinical applications. In this review, we highlighted the recent novel techniques for malignant glioma treatment, including cell encapsulation technique, gene therapy, nanotechnology, stem cell-based therapy, immunotherapy, and targeted therapy.

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