The Role of HPV 16 E5 Protein and Its Interacting Partners in Cervical Cancer Cases

Abstract

Human papillomavirus (HPV) is one of the most common causal agents of sexually transmitted disease in both men and women worldwide. In developing countries, cervical cancer is the most common cancer in women and may constitute up to 25% of all female cancers. Cervical cancer is preceded only by breast cancer as the most common cause of death from cancer in women worldwide. The link between genital HPV infections and cervical cancer (CaCx) was first demonstrated in the early 1980s. From this link of HPV with CaCx researchers identified some oncogenes of HPV which are playing a major role in CaCx pathogenesis. These oncogenes are E5, E6 and E7. The role of oncogene E6 and E7 are extensively studied than E5. This article will review the role of HPV 16 E5 oncoprotein and its interacting partners in the progression of cervical cancer (CaCx).