Hypotheses and Emerging Facts: the Vitamin D Receptor Capacitor, Rheumatoid Arthritis and Beyond

Yue Zhang

Abstract


As System-IN Failing, complex diseases such as autoimmune diseases (ADs) like rheumatic arthritis (RA), and the associated cancers remain as a challenge to thoroughly understand, though their common underlying mechanisms emerge. In this visionary article, we summarize some recent hypothesis-generating discussions on the Vitamin D and its receptor (VDR) capacitor for autoimmune diseases (ADs) and associated cancers, then update bioinformatics evidence along with latest progress in RA. We could conclude this may provide one unique angle to view the controversies surrounding the beneficial effects of Vitamin D supplementation.

Keywords


Rheumatoid arthritis; Autoimmune disaeses; Vitamin D receptor capacitor; Cancer; Prevention

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