Relationship between Glycated Haemoglobin and Complexity of Coronary Artery Disease in Diabetic Patients

Abstract

AIM: The aim of this study is to examine the relation between glycated haemoglobin (HbA1c) and complexity of coronary artery lesion.

METHODS: This study enrolled 80 diabetic patients who underwent their first elective coronary angiography and had their HbA1c levels measured at Menoufia University Hospital between September 2015 and September 2016. The complexity of the coronary artery lesions were evaluated using syntax score. Logistic regression and correlation coefficient were used to analyze the association between the measured HbA1c levels and syntax score.

RESULTS: Eighty diabetic patients with a mean age 60 ± 8.1 years underwent elective coronary angiography with pre-procedural measurement of HbA1c were included. Increased and a higher HbA1c levels were significantly associated with a higher syntax score (p value < 0.001). After adjustment of age, gender, smoking, hypertension, dyslipidaemia and duration of diabetes, it was found that a higher HbA1c levels were able to independently predict patients with intermediate or high syntax score (≥ 18).

CONCLUSION: The complexity of coronary artery lesions was significantly correlated with HbA1c among diabetic patients. A higher HbA1c value is an independent predictor of the complexity of coronary lesions.