MicroRnas in Ischemic Stroke: From Animal Studies to Preclinical Research

Gabor Kiss, Gergely Feher, David Hesszenberger, Katalin Koltai, Gabriella Pusch, Antal Tibold

Abstract


Introduction: MicroRNAs (miRNAs) constitute a class of endogenous small non-coding RNAs. Expandig evidence evidence indicates that a set of miRNAs, expressed in a spatially and temporally controlled manner in the brain, are involved in neuronal development, differentiation and synaptic plasticity.

Aim: The aim of our review was to summarize the the role of miRNAs in the development of ischemic stroke based on animal and human and preclinical treatment studies.

Conclusion: Disregulated miRNAs have revealed their complex role in pathophysiological processes in both animal and human research, and have also shown their potential role in disease diagnosis, and use as drug targets in ischemic stroke. Although miRNAs represent a potentially powerful treatment paradigm, much work remains to be done in describing individual specific miRNA-mRNA interactions, understanding the regional and cell type specific distribution of miRNAs within the nervous system, and in developing organ-targeted delivery systems to optimize the therapeutic potential of miRNAs.


Keywords


Ischemic stroke; MicroRNA; Animal model; Human study; Preclinical research; Pathophysiology; Treatment

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