New Strategies for the Treatment of Dilated Cardiomyopathy

Abstract

Dilated cardiomyopathy (DCM) is a type of cardiomyopathy that is characterized by an enlarged left ventricle or double ventricle accompanied by systolic dysfunction. It is a heterogeneous cardiomyopathy. It has an insidious onset and complicated aetiology, and its pathogenesis is unclear. The traditional treatment methods for this condition include drugs and surgery. These methods can only help relieve the symptoms, as the condition cannot be permanently cured. Therefore, there is an urgent need to develop specific targeted therapies to treat dilated cardiomyopathy. This review aimed to introduce the aetiology and clinical manifestations of dilated cardiomyopathy, discuss the advantages and disadvantages of its traditional treatment methods and focus on gene- and cell-based targeted therapy strategies.