Nodular-cystic fat necrosis-A review of 147 Japanese patients

Abstract

Nodular-cystic fat necrosis, which is also called encapsulated fat necrosis, is a mobile subcutaneous nodule and histologically reveals fat necrosis encapsulated by fibrous connective tissue. In Japan, many cases have been reported, and there are some opinions that diabetes mellitus and systemic corticosteroid therapy cause this condition. The author found that out of 147 Japanese patients reported from 1982 up to 2015, 9 had the former and 23 received the latter. Systemic corticosteroid therapy may be responsible for nodular-cystic fat necrosis.