http://ghrnet.org/index.php/jdr/issue/feedJournal of Dermatological Research2022-05-30T00:58:59-04:00Journal of Dermatological Researchjdr@ghrnet.orgOpen Journal SystemsAuthors publishing in the Journal will be asked to sign a Copyright Transfer Agreement. In signing the form it is assumed that authors have obtained permission to use any copyrighted or previously published material. All authors must read and agree to the conditions outlined in the form, and must sign the form or agree that the corresponding author can sign on their behalf. Articles cannot be published until a signed form has been received.ISSN: 2413-8223<br /> Frequency: Biannually, Instant published<br />Journal Access: Open Access<br />The first Issue: April, 2016<br /> Publsihing fee<br />http://ghrnet.org/index.php/jdr/article/view/3187Role of Histamine on Itch Sensation Induced by Interleukin-312022-05-30T00:58:59-04:00Masahiro Seikem-seike@star.sagami-wu.ac.jp<p>Chronic allergic dermatitis, including atopic dermatitis and chronic allergic contact dermatitis, is characterized by an itch sensation and eczematous lesions, along with T helper (Th) 2 cell and granulocyte infiltration. Th2 cells, mast cells and eosinophils secrete interleukin (IL)-31, inducing intense itching in allergic dermatitis. Regulatory T cells (Tregs) inhibit the infiltration of these cells. Histamine induces the development of eczematous lesions in patients with chronic allergic dermatitis. In these eczematous lesions, histamine induces cell infiltration and inhibits Treg infiltration via histamine H1 and H4 receptors. Therefore, histamine may aggravate the itch sensation during chronic allergic dermatitis by increasing IL-31 levels.</p>2022-05-30T00:00:00-04:00