Is Response to Enuresis Treatment with Desmopressin Influenced by Family History, Associated Comorbidities or Obesity?

Abstract

Aim: To evaluate the role of family history of enuresis, associated comorbidities and body mass index in predicting response to enuresis treatment with desmopressin in children.

Materials amd methods: 100 patients with monosymptomatic enuresis were evaluated in this retrospective study. The associations between family history of enuresis, associated comorbidities, body mass index and response to enuresis treatment with desmopressin were analysed with χ² statistical test.

Results: Family history of enuresis was positive in 58.8 % of patients who responded to desmopressin treatment and in 54.5 % of non-responders. Among patients who responded to desmopressin treatment, obesity was present in 14.3 % and overweight in 19 % of patients. Among non-responders, obesity was present in 13.2 % and overweight in 7.9 % of patients. Among patients who responded to desmopressin treatment, comorbidity was present in 40.5 % of patients. Among 38 non-responders, comorbidity was present in 21.1 %  of patients. The difference was not statistically significant in either of compared groups.

Conclusion: The study did not prove statistically significant association between family history of enuresis, associated comorbidities or body mass index, and response to treatment with desmopressin.