Ameliorative Potentials Of Cyperus Esculentus Oil On Type 2 Diabetes Induced By High Fat Diet And Low Dose Streptozotocin In Male Wistar Rats

Abstract

The aim of this study is to investigate the ameliorative potentials of Cyperus esculentus (Tigernut) oil, in type 2 diabetes induced with the combination of high fat diet and a low dose streptozotocin (35mg/kg) in male Wistar rats. Forty rats weighing between 100-115g were divided randomly into group of five (n=8), 3 groups were subsequently fed with a high fat diet (HFD) for 30 days and the other 2 were maintained on normal rat chow (NPD). Results revealed an increase in body weight amongst the groups fed with a HFD and treatment with C. esculentus oil significantly (P<0.05) reduced the body weight (HFD+STZ+CEO). Glycated hemoglobin (HbAIC), G6PDH and α-Amylase activity were significantly stabilized in C.esculentus oil treated group. Oral glucose tolerant test with a load dose of 150 mg/kg glucose showed there was a rapid blood sugar level clearance in HFD+STZ+CEO as compared to untreated group (HFD+STZ). Atherogenic index (AIP) levels was significantly (p<0.05) lowered in the treated groups (HFD+STZ+GLI 0.262±0.40 and HFD+STZ+CEO 0.18±0.03) when compared to untreated groups (HFD+STZ 0.495±0.66 and NFD+STZ 0.495±0.57) as well as Triglyceride and VLDL levels. Enzymatic antioxidants activities were enhanced by C. esculentus oil. Therefore, C. esculentus oil may be used as either a therapeutic agent or as a dietary choice for the management of type 2 diabetes.