Protein C and Antithrombin III Activities in Healthy Nigerian Women

Abstract

Aim: In order to ensure that thrombin generation is limited and localised to prevent thrombosis after minor injury, coagulation inhibitors play a vital role. The study assessed protein C and antithrombin III levels in pregnant women in Kano, North-Western Nigeria. Materials and methods: A total of two-hundred and fifty apparently healthy subjects (150 pregnant and 100 non-pregnant women), aged 17-40 years were recruited for the study in Aminu Kano Teaching Hospital, Kano between August 2010 and October 2011. Blood samples collected were analysed for Protein C and antithrombin III activities using standard laboratory procedures. Results: There was significantly lower value of proteins C activity in pregnant women compared to non-pregnant women (P<0.05) while the values of antithrombin III in pregnant and non-pregnant women showed no statistically significant difference (P>0.05). Different and fluctuated values of Protein C activities and antithrombin III activities with regard to first, second and third trimesters respectively, showed no significant differences (P>0.05). Maternal age and parity had no significant influences on protein C and antithrombin III activities. Conclusion: Pregnancy is associated with significantly lower value of protein C activity while antithrombin level remained stable and unchanged. Gestational age, maternal age and parity showed no influences in protein C and antithrombin III activities. It is recommended that protein C activity be assessed in pregnant women to avoid thromboembolism.