The Impact beyond Recombinant Antibody: Recent Advances in Understanding the Disease Associated Glycan Alterations in Endogenous Antibodies

Abstract

Antibodies, or immunoglobulins,play a critical role in humoral immune response.  They have been used as important therapeutics for treatment of cancer and autoimmune diseases.  There are glycans which are attached to N297 at a well conserved N-glycosylation site in C_H2domain of IgG Fc region.Unlike those present in other glycoproteins, the N297 glycans aremainly truncated fucosylated biantennary complex-type structures with minimal amounts of sialic acid.