Angiofibroma of Soft Tissue Occurring in Subcutaneous Adipose Tissue and Appearing as Subcutaneous Nodules

Abstract

Angiofibroma of soft tissue is a new entity recently proposed. It appears often in the deep tissue in relation to joints or fibrotendinous structures. Dermatologists may encounter the cases in the slightly shallow tissue. We report three cases occurring in subcutaneous adipose tissue, and clinically appearing as subcutaneous nodules. A 71-year-old male, an eight-year-old male and a 36-year-old female had a 15-mm-diameter nodule on the left buttock, a 10×5 mm one on the lower right heel and a 15×12 mm one on the lateral right dorsum, respectively. The lesions revealed histologically a proliferation of spindle cells in the collagenous or myxoid-to-collagenous stroma, and abundant branching slit-like vascular structures.