Vitamin D is it a key in Egyptian NAFLD Pathogenesis?

Abstract

AIM: To analyze the association of serum vitamin D level assessed by 25-hydroxyvitamin D3 {25(OH)D3 } with nonalcoholic fatty liver disease (NAFLD). METHODS: 104 urban subjects recruited from Gastroenterology Out-patients Clinic in El Sahel Teaching Hospital prospectively. The study participants divided into two groups: 57 (54.8%) cases of NAFLD (31 males, 26 females) and 47 (45%) healthy controls (21 males and 26 females). Serum 25 (OH) vitamin was measured for all participants. Results: there is significant decrease of vit D level in NAFLD group 53.53±42.47 in correlation to control 97.91 ±27.16, p˂0.001.Also there is significant increased in BMI and glucose of NAFLD group than control, 33.14±5.07, 25±3.69 and 111.58±20.30, 99.83 ±10.63, p˂0.001 but no statistically significant difference in TG . Conclusion: Vit D deficiency is an important cause in NAFLD pathogens is as well as MS.