Not So (A) Cute: Chronic Evolution of Hepatitis E Virus
Abstract
Although HEV causes self-limiting acute infection, an atypical
clinical presentation with persistent viremia in immunocompromised
individuals has emerged recently, in developed countries. In
the absence of travel to endemic regions, indigenous HEV infection
due to zoonotic viral strains are implicated in such chronic
cases. Presently, IFN-α-2a and Ribavirin are proving effective in
treating chronic hepatitis E patients.The underlying mechanisms of
this chronic adaptation is poorly understood so far and therefore, a
comprehensive clinical, virological and molecular study is needed
to control the disease.
clinical presentation with persistent viremia in immunocompromised
individuals has emerged recently, in developed countries. In
the absence of travel to endemic regions, indigenous HEV infection
due to zoonotic viral strains are implicated in such chronic
cases. Presently, IFN-α-2a and Ribavirin are proving effective in
treating chronic hepatitis E patients.The underlying mechanisms of
this chronic adaptation is poorly understood so far and therefore, a
comprehensive clinical, virological and molecular study is needed
to control the disease.
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