Zinc Status in Exocrine Pancreatic Insufficiency: A Systematic Review

Sarah Fast, John V. Logomarsino


AIM: The present systematic review looks to available research to determine the effect of exocrine pancreatic insufficiency on zinc status.

MATERIALS AND METHODS: An exhaustive search was conducted amongst six databases up to September 2017 for studies reporting zinc status in patients with diagnosed exocrine pancreatic insufficiency. Thirteen studies of observational design met inclusion criteria.

RESULTS: Eleven of the 13 studies included in this review found an association between zinc status and exocrine pancreatic insufficiency. Most of these studies found a correlation between zinc status and the degree of exocrine pancreatic insufficiency. However, considering the nature of the observational study design of the included studies, the strength of the evidence is low.

CONCLUSION: Those with exocrine pancreatic insufficiency may be at high risk for impaired zinc status. Larger, high-quality studies are necessary to estimate the prevalence of zinc deficiency and before clinicians routinely recommend supplementation.


Exocrine Pancreatic Insufficiency, Zinc Deficiency, Zinc

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