Mucinous adenocarcinoma of the rectum in a 13-year-old child - a case report
Abstract
Although colorectal carcinoma (CRC) is the second most common primary gastrointestinal system malignancies in children after liver tumors, it is extremely rare in pediatric age. Due to the lack of awareness of the disease, diagnosis is usually delayed till it is in advanced stage, leading to a poor prognosis as compared to adults. We present a case of CRC in a 13-year-old girl who presented with abdominal pain, vomiting and unintentional weight loss. Clinical examination and imaging did not reveal a clear pathology. On exploration, a marked circumferential thickening of the wall of the sigmoid colon and the rectum was noted. Biopsies proved to be a mucinous adenocarcinoma of the rectosigmoid, infiltrating the wall till subserosal fat.
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References
Khan AM, Doig CM, Dickson AP. Advanced colonic carcinoma in children. Postgrad Med J. 1997;73:169-170. [doi.org/10.1136/pgmj.73.857.169]
Wyllie R, Hyams JS, Kay M, (eds). Pediatric Gastrointestinal and Liver Disease. 4th ed. Philadelphia: Saunders; 2011.
Jeong YJ, Lee MR, Kim JC, Hwang PH, Moon WS, Chung MJ. Carcinosarcoma of the rectosigmoid colon in a 13-year-old girl. Pathol Int. 2008;58:445-450. [DOI: 10.1111/j.1440-1827.2008.02252.x]
Ferrari A, Rognone A, Casanova M, Zaffignani E, Piva L, Collini P, Bertario L, Sala P, Leo E, Belli F, Gallino G. Colorectal carcinoma in children and adolescents: the experience of the Istituto Nazionale Tumori of Milan, Italy. Pediatr Blood Cancer. 2008;50:588-593.
Salas-Valverde S, Lizano A, Gamboa Y, Vega S, Barrantes M, Santamaría S, Zamora JB. Colon carcinoma in children and adolescents: prognostic factors and outcome-a review of 11 cases. Pediatr Surg Int. 2009; 25:1073-1076. [DOI: 10.1007/s00383-009-2491-y]
Chattopadhyay S, Gupta P, Aich RK, Deb AR. Colorectal carcinoma in a ten-year-old girl: a case report. J Cancer Res Ther. 2012;8:120-122. [DOI: 10.4103/0973-1482.95189]
Al-Tonbary Y, Darwish A, El-Hussein A, Fouda A. Adenocarcinoma of the colon in children: case series and mini-review of the literature. Hematol Oncol Stem Cell Ther. 2013;6:29-33. [DOI: 10.1016/j.hemonc.2013.02.003]
Malik R, Kamath N. Anorectal mucinous adenocarcinoma in child: a case report. Eur J Pediatr. 2011;170:1461-1463. [DOI: 10.1007/s00431-011-1527-1]
Agrawal P, Rajwanshi A, Gupta N, Rao KL. Mucinous adenocarcinoma of rectum in an 11-year-old boy: a case report. Diagn Cytopathol. 2012;40:252-554. [DOI: 10.1002/dc.21627]
Hill DA, Furman WL, Billups CA, Riedley SE, Cain AM, Rao BN, Pratt CB, Spunt SL. Colorectal carcinoma in childhood and adolescence: a clinicopathologic review. J Clin Oncol. 2007;25:5808-5814.
Smith D, Ballal M, Hodder R, Soin G, Selvachandran SN, Cade D. Symptomatic presentation of early colorectal cancer. Ann R Coll Surg Engl 2006;88:185-190.
Yamagishi H, Kuroda H, Imai Y, Hiraishi H. Molecular pathogenesis of sporadic colorectal cancers. Chin J Cancer. 2016; 35:4. [DOI:10.1186/s40880-015-0066-y]
Singer G, Hoellwarth ME. Colorectal carcinomas in children: an institutional experience. Pediatr Surg Int. 2012; 28:591-595. [DOI: 10.1007/s00383-012-3090-x]
Furman WL, Tricoli JV. Important considerations in treating children, adolescents and young adults with colorectal carcinoma. Colorectal Cancer. 2013;2:347-358. [doi.org/10.2217/crc.13.40]
Koh KJ, Lin LH, Huang SH, Wong JU. CARE - pediatric colon adenocarcinoma: a case report and literature review comparing differences in clinical features between children and adult patients. Medicine. 2015;94:e503. [DOI: 10.1097/MD.0000000000000503]
Riihimäki M, Hemminki A, Sundquist J, Hemminki K. Patterns of metastasis in colon and rectal cancer. Sci Rep. 2016;6:29765. [DOI: 10.1038/srep29765]
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