Association of Butyrate Fermented in Aloe vera gel with α-Synuclein-induced DNA and Histone Damages in Parkinson’s Disease Patients. Case reports: Remission of PD Patients with Diabetes, Drug-induced Parkinsonism, and Irritable Bowel Syndrome with Aloe ve

Abstract

α-Synuclein misfolding and aggregation are linked to the Parkinson’s disease (PD) pathology. PD may begin with the intestinal accumulation of α-Syn fibrils, which can be casually associated with gut dysbiosis. The variability of gut microbiota across countries prevented us from identifying shared gut dysbiosis in PD. The intestinal mucin layer-degrading Akkermanisia is increased and short chain fatty acids-producing Roseburia and Faecaibavyerium are decreased in PD across countries. We discussed the relevance of gut microbiota, short chain fatty acids, butyrate, and gut dysbiosis in PD in disease progression. In case reports, remission of PD patients with diabetes and drug-induced Parkinsonism and irritable bowel syndrome with drug and aloe vera juice supplements as an adjuvant were exhibited.