Therapeutic Efficacy of Aloe Vera high Molecular Fractions for Treatment of Hepatic Fibrosis, Type 2 Diabetes, Bed Sores and Lichen Planus

Abstract

Aloe vera gel has been widely used for healing of burn wound and hepatitis with paucity of therapeutic evidence. One of the unclear therapeutic indications may be responsible to contamination and variation of coloured materials and ingredients in aloe vera gel. Aloe vera gel is separated from the rind of the leaf by filleting and separating the inner gel from the outer leaf rind with mechanical or handle way. Due to the differences in biological ingredients of test products, therapeutic evaluation may be variable. Coloured materials in aloe vera leaf gel, such as barbaloin and aloe-emodin with carginogenicity, could not be completely removed without processing by charcoal treatment. The quality control of the biologically active principles is necessary for therapeutic applications. By using the patented hyper-dry system after washing out coloured materials with running water, aloe high molecular fractions (AHM) were obtained in original and natural form containing less than 10 ppm of barbaloin. AHM mainly contained high molecular fractions, such as polysacharide (acemannan) and glycoprotein (verectin) showing immunomodulatory and anti-inflammatory activities. On the basis of chemical and biochemical properties, AHM were examined for the therapy designed by the implementation of well-controlled clinical trials, and exhibited the efficacy as immunomodulators for viral infection-induced hepatic periportal fibrosis and type 2 diabetic patients, and as wound and ulcer-healing ointment to patients suffering from bed sore and lichen planus. Therefore, AHM were considered to be a novel low-cost and safe drug of natural origin, indicating a possible therapeutic efficacy in prevention of age-related diseases by slowing aging process.