Pancreatic Serous Cystadenocarcinoma – A Case Report

Abstract

True malignant cystic neoplasms are rare tumors and account for only about 1-3% of all pancreatic tumors. Serous cystadenocarcinomas are very rare and to the best of our knowledge, about 15 cases have been reported in the literature so far. A 45 years old female presented with complaints of upper abdominal pain radiating towards back. CT scan upper abdomen showed a large heterogeneous mass arising from the body of the pancreas. It was inseparable from the spleen. A distal pancreatectomy with splenectomy was planned. The specimen received weighed 860 grams. Pancreas measured 13 x 11x 9 cm. There was a 10 x 10 x 9 cm tumor with lobulated external surface. Microscopic examination revealed small cyst lined by cuboidal cells having clear cytoplasm and round predominantly uniform hyperchromatic nuclei. The tumor cells demonstrated glycogen in periodic acid schiff (PAS) stain. The tumor invaded the splenic parenchyma. Foci of dystrophic calcification were present. The tumor was diagnosed as cystadenocarcinoma. Cystic neoplasms of pancreas are rare tumors but they should be thoroughly investigated as these lesions tend to have potential for malignant transformation.