Insulin resistance and cognitive impairment in type II diabetes mellitus

Mostafa M Gaber, Eman M Khedr, Marwa Ahmed, Sally A Sayed



Roriz-Filho J.S., Sá-Roriz T.M., Rosset I., Camozzato A.L., Santos A.C. Rydgren T., Börjesson A., Carlsson A. & Sandler S. (2012): Elevated glucagon-like peptide-1 plasma levels, as a possible adaptive response, in diabetic NOD mice. Biochem Biophys Res Commun. 6;423(3), 583-587.

Ricardo B. M., Gonzalo F., Inelia M. & Leonardo N. (2010): The Revitalized Tau Hypothesis on Alzheimer’s Disease Ricardo. Archives of Medical Research 41, 226-231

Ahmed I. & Goldstein B.J. (2006): Cardiovascular risk in the spectrum of type 2 diabetes mellitus. Mt. Sinai J. Med. 73, 759–768.

Zhao W.Q. & Alkon, D.L. (2001): Role of insulin and insulin receptor in learning and memory. Mol. Cell. Endocrinol. 177, 125–134.

Sima A.A., Kamiya H. and Li Z.G. (2004): Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes. Eur J. Pharmacol 19;490(1-3):187-97.

Biessels G.J., Staekenborg S., Brunner E., Brayne C. & Scheltens P., (2006): Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol. 5, 64–74.

Hazari M. A., Reddy B. R., Uzma N.& Kumar B. S. (2011): Cognitive impairment in type 2 diabetes mellitus. International Journal of Diabetes Mellitus article.3(1),19-24.

Axelrod B. N. (2001): Administration duration for the Wechsler Adult Intelligence Scale-III and Wechsler Memory Scale-III. Archives of Clinical NeuropsychologyVol. 16; 3, 293–301.

Polich J. (2007): Attention, probability, and task demands as determinants of P300 latency from auditory stimuli. Electroencephalogr. Clin. Neurophysiol. 63, 251–259.

Awad N. , Gagnon M. & Messier C. (2004): The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function, J. Clin. Exp. Neuropsychol. 26 (8) , 1044–1080.

Mitra J. Parvin Z.M., Mohammad R et al. (2010): development of ph-sensitive insulin nanoparticles using eudragit l100-55 and chitosan with different molecular weights, AAPS PharmSciTech, 11( 3): 1237-1242.

Gao Y., Xiao Y., Miao R., Zhao J., Zhang W., Huang G. & Ma F. (2015): The characteristic of cognitive function in Type 2 diabetes mellitus. Diabetes Res Clin Pract;109(2): 299-305.

Helkala E. L., Niskanen L., Viinamaki H., Partanen J. & Uusitupa M. (1995): Short-term and long-term memory in elderly patients with NIDDM, Diabetes Care 18 , 681.

Cosway R., Strachan M.W., Dougall A., Frier B.M. & Deary I.J. (2009): Cognitive function and information processing in type 2 diabetes. Diabet Med. 18(10):803-810.

Heinze H. J., MuÈnte T. F., Kutas M., Butler S.R. , NaÈaÈtaÈnen R., Nuwer M.R. & Goodin D.S. (1992):Cognitive event-related potentials Guidelines of the International Federation of Clinical Physiology (EEG Suppl. 52).

Chen P, Ratcliff G, Belle SH, Cauley JA, DeKosky ST, Ganguli M. (2003):Patterns of cognitive decline in presymptomatic Alzheimer disease: a prospective community study.Arch Gen Psychiatry;58:853–858.

Ajilore O., Haroon E., Kumaran S., Darwin C., Binesh N., Mintz J., Miller J., Thomas M.A. & Kumar A. (2007): Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy. Neuropsycho-pharmacology. 32(6),1224-1231.

Van der Heide L. P., Ramakers G. M. J. & Smidt M. P. (2006): Insulin signaling in the central nervous system: learning to survive. Progress in Neurobiology, 79(4), 205–221.

Biessels G.J. & Kappelle L.J. (2005): Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology? Biochem. Soc. Trans. 33, 1041–1044.

Cunnane S., Nugent, S. Roy, M., Courchesne-Loyer A., Croteau E., Tremblay S. & Rapoport S. I. (2011): Brain fuel metabolism, aging, and Alzheimer’s disease. Nutrition (Burbank, Los Angeles County, Calif.), 27(1), 3–20.

Tang J., Pei Y. & Zhou G. (2013): When aging-onset diabetes is coming across with Alzheimer disease: comparable pathogenesis and therapy Experimental Gerontology Vol. 48 (8), 744–750

Full Text: PDF HTML


  • There are currently no refbacks.

Creative Commons License
This work is licensed under a Creative Commons Attribution 3.0 License.