Corticotropin-Releasing Hormone Receptor 1 Antagonist With or Without Corticotropin-Releasing Hormone Receptor 2 Remain Promising in Relieving Human Acute Psychological Stress and Related Intestinal Hyperpermeability

Abstract

Corticotropin-releasing hormone (CRH) has clinical relevant to stress, feeding behavior, gut motility and immunity. Emerging evidence indicates that two CRH receptor subtypes, receptor 1 (CRH1-R) and 2 (CRH2-R), play pivotal roles in the regulation of these biological functions induced by CRH, depending on which receptor subtypes to be activated. Manipulating and balancing at CRH1-R and CRH2-R has become a novel concept to treat stress-related disorders and gut dysfunction, such as psychological stress and related intestinal hyperpermeability.