Regulation of Zhiyixiao on the Expression of Visfatin in NAFLD Rats

Abstract

AIM: To observe the effect of ZhiYiXiao on NAFLD rats’ liver pathology and Visfatin levels and to explore the mechanism of NAFLD by “ZhiYiXiao.” Methods: NAFLD rats were prepared with a high-fat diet. Rats were divided into low, medium, and high doses of ZhiYiXiao treatment groups, YiShanFu positive control group, saline negative control group, and a normal control group. The RT-PCR method was used to detect the expression of Visfatin mRNA in liver tissue, and ELISA was used to detect the expression of Visfatin’s protein. Results: The expression of Visfatin mRNA and protein was significantly lower in liver tissue (P<0.01). However, compared with the YiShanFu group, each dose group showed no significant difference (P>0.05). Conclusion: ZhiYiXiao can regulate the expressions of Visfatin in liver tissue and can reduce the expressions of Visfatin mRNA and protein; its efficacy is similar to YiShanFu (P>0.05). The mechanism of action by ZhiYiXiao may be related to the regulation of the expression of Visfatin in liver tissue.