Prevalence of Amebiasis among Histologically confirmed colitis patients
Abstract
ABSTRACT
Background and study aim: Amebiasis is a prevalent infection worldwide and associated with colitis that may mimic different types of colitis. The aim of this study is to determine the prevalence of amebiasis among patients with endoscopically and histologically confirmed colitis among Egyptian patients.
Patients and Methods: This study was conducted in the period from June 2017 to March 2018. Patients in the final analysis were divided into 2 groups according to their histopathologic features: Group I: Inflammatory bowel disease (IBD) patients comprised 60, 49 patients diagnosed as ulcerative colitis (UC) and 11 patients diagnosed as Crohn’s disease (CD). Group II: Non-specific colitis. Comprised a total of 100 patients.
Results
The prevalence of Entamoeba histolytica cysts and trophozoits among the study patients was 9.37% (15/160). They were 11 patients with IBD (6.87%) cases and 4 patients with non- specific colitis (2.5%). Patients with non- specific colitis are younger in age, had less blood levels of CRP and lower prevalence rates of amebiasis when compared with IBD patients. When patients with IBD were compared as ulcerative colitis and Crohn's disease it seem that the younger age CD did not show different prevalence rates of amebiasis when compared with UC (P value 1).
Conclusions:
The prevalence of amebiasis in histologically confirmed colitis is 9.37% (15/160). They were 11 patients with IBD (6.87%) cases and 4 patients with non- specific colitis (2.5%). Regarding IBD the prevalence of amebiasis was 11 patients/out of 60 (18.3%) and prevalence was higher in ulcerative colitis when compared with Crohn’s disease with figure of 9 patients (15%) and 2 patients (3.3%) respectively. Further studies are needed to clarify the impact of amebiais on the course of IBD and non-specific colitis.
Keywords
References
REFERENCES
Bercu TE, Petri WA, Behm JW. Amebic colitis: new insights into pathogenesis and treatment. Curr Gastroenterol Rep 2007; 9:429.
Peterson KM, Singh U, Petri WA Jr. Enteric Amebiasis. In: Tropical Infectious Diseases: Principles, Pathogens and Practice, 3rd ed, Guerrant R, Walker DH, Weller PF (Eds), Saunders Elsevier, Philadelphia 2011. p.614.
Haque R, Huston CD, Hughes M, Houpt E, Petri WA. Amebiasis. N Engl J Med. 2003;348: 1565–1573
Patel AS, DeRidder PH. Amoebic colitis masquerading as acute inflammatory bowel disease: the role of serology in its diagnosis. J Clin Gastroenterol 1989; 11(4):407-410.
Addib O, Ziglam H, Conlong P. Invasive amoebiasis complicating iflammatory bowel disease. Libyan J Med. 2007 1;2(4):214-5.
Singh R, Balekuduru A, Simon EG, Alexander M, Pulimood A. The differentiation of amebic colitis from inflammatory bowel disease on endoscopic mucosal biopsies. Indian J Pathol Microbiol. 2015;58(4):427-32.
Carleton H.M., Drury R.A.B., Wallington,E.A.: Carleton’s histological techniques, 5th edition, volume 243. Carleton,H.M., Drury,R.A.B. and Wallington,E.A. (editors). Oxford University Press, New York, 1980 p. 417.
Ustun S, Dagci H, Aksoy U, Guruz Y, Ersoz G. Prevalence of amebiasis in inflammatory bowel disease in Turkey. World J Gastroenterol 2003; 9(8): 1834-1835.
Babić E, Bevanda M, Mimica M, Karin M, Volarić M, Bogut A, Barišić T, Pravdić D, Šutalo N et al. Prevalence of amebiasis in inflammatory bowel disease in University Clinical Hospital Mostar. SpringerPlus 2016; 5:1586
Saad EA, Mourad AA, Mahmoud AM, Hussien HI, Elhawari SA. Emara MH, Mohamed SM. Impact of Treatment of Intestinal Parasites on the Activity of Ulcerative Colitis. Afro-Egypt J Infect Endem Dis 2013; 3(3): 96-104.
Refbacks
- There are currently no refbacks.
This work is licensed under a Creative Commons Attribution 3.0 License.