Olmesartan Induced Enteropathy

Abstract

61 year old man, presented with 2 weeks of watery diarrhoea, up to 20 times/day associated with 10 kg weight loss and decreased urine output. He denied travel history and antibiotic used prior to admission. His past medical history included hypertension and gastro-oesophageal reflux disease, taking Pantoprazole 40 mg daily, Olmesartan 40 mg/Amlodipine 10 mg/Hydrochlorothiazide 25 mg daily, and Atenolol 50 mg daily. On admission, urea was 32.5 mmol/L, Cr 699 umol/L secondary to severe dehydration, responded well to intravenous fluid therapy, and normalised Cr within 5 days, but ongoing diarrhoea. All antihypertensive medications were ceased on admission and recommenced 3 days after.