Aloe Vera High Molecular Weight Fractions as Carbohydratebased Immune Adjuvants

Abstract

By using the patented hyper-dry system after washing out coloured materials with running water, aloe high molecular fractions (AHM) were obtained in original and natural form containing less than 10 ppm of barbaloin. AHM mainly contained high molecular fractions, such as polysaccharide (acemannan) and glycoprotein (verectin) showing immunomodulatory and anti-inflammatory activities. On the basis of chemical and biochemical properties, AHM were examined for the therapy designed by the implementation of well-controlled clinical trials, and exhibited the efficacy as immunomodulators for viral infection-induced hepatic periportal fibrosis and type 2 diabetic patients, and as wound and ulcer-healing ointment to patients suffering from bedsore. Therefore, AHM were considered to be a novel low-cost and safe drug of natural origin, indicating a possible therapeutic efficacy in prevention of age-related diseases.