Possible Efficacy of aloe vera gel Metabolites in Long-Term Ingestion to Insulin Sensitivity

Abstract

Diet metabolism and immunomodulatory activity are linked to both to each other, allowing mammals to adapt to diverse changes in their intestinal gut surroundings. The obesity as a primary source of disease brings about metabolic dysfunction followed by inflammatory insulin resistance. The metabolites of aloe polymannose moiety, such as a mannooligosaccharide and short chain fatty acids, synergistically modulated insulin sensitivity on tissues with combination of phenolics, such as aloesin, aloe emodin (a metabolite of barbaloin) and salicylate in aloe vera gel. The insulin levels and insulin activity in the central nerve system, such as hippocampus, are reduced in Alzheimer's disease (AD) and amnestic mild cognitive impairment (MCI). Restoring insulin levels to normal in the brain may provide therapeutic benefit to elderly subjects with AD and amnestic MCI. The effect of aloe polymannose multinutrients complex (APMC) on cognitive and immune functioning in AD showed the improvements in both clinical and physiological outcomes, though the several limitations of the current investigation were noted. APMC may offer an alternative opinion for persons with AD and amnestic MCI. Present review showed a possible putative efficacy of aloe vera gel metabolites in long-term ingestion to insulin sensitivity.